ATAC-seq
Map genome-wide chromatin accessibility, revealing regulatory regions and active DNA elements
Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is a powerful method for profiling open chromatin regions across the genome. By leveraging a hyperactive Tn5 transposase, ATAC-seq integrates sequencing adapters directly into accessible DNA, enabling researchers to map regulatory elements such as promoters, enhancers, and transcription factor binding sites with high sensitivity and low input requirements.
At Admera, our ATAC-seq services provide comprehensive insights into chromatin dynamics to support projects in gene regulation, epigenetic research, and drug discovery. With optimized protocols, rigorous QC, and expert bioinformatics support, we deliver high-resolution data that helps researchers understand how chromatin accessibility shapes gene expression and cellular states.
What is ATAC-seq?
Applications
Cell-type specific chromatin landscapes
Distinguish regulatory elements across tissues, developmental stages, or disease states
Biomarker & Therapeutic Target Discovery
Detect accessible regions associated with disease phenotypes or treatment responses.
Cancer Research
Identify tumor-specific regulatory elements and uncover mechanisms of oncogene activation or tumor suppressor silencing.
Utilize ATAC-seq with single-cell RNA-seq to simultaneously capture chromatin access
Single-cell epigenome profiling
Frequently Asked Questions
Sending samples? See our DNA sample submission guidelines for best practices on sample preparation, packaging, and shipment for the highest quality results.
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We primarily work with cells, tissue, and transposed DNA for ATAC-seq projects. Please contact us if you have further questions about sample requirements.
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If your sample does not meet our quality control standards at any point in the workflow, we will contact you immediately. We will discuss the specific failure point and provide options, which may include re-submitting the sample, proceeding with a modified workflow, or canceling the project. We believe in transparency and working with you to achieve the best possible outcome.
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Our standard turnaround time is typically 15-20 business days, though this can vary depending on the sample type, project complexity, and required sequencing depth. Expedited services are available upon request. Please contact us for a detailed quote and timeline specific to your project.
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Standard bioinformatic analysis includes: Preliminary QC and trimming, genome alignment, duplicate removal, alignment QC, normalization, annotation, enrichment analysis, peak calling and QC, clustering, differential analysis, functional analysis, combined density profile analysis, and motif analysis.
Our team of bioinformaticians can create tailored solutions for additional analysis. Contact us to speak with an expert who can align your data analysis project.
Get the Most out of Your Study
Maximize your project’s potential with advanced analysis solutions. Our team of expert bioinformaticians curate pipelines tailored to your project’s experimental design.
See ATAC-seq in Action
Admera Health provides comprehensive support for all projects, and delivers publication-ready data. Discover how researchers are using Admera Health to advance their studies.